Cell death & disease
Targeting FOXM1 regulates metabolic signatures through ROS-dependent JNK/Bmi1/Skp2 axis in human cutaneous T-cell lymphoma.
Abdul Q Khan, Maha Agha, Fareed Ahmad, Rasheeda Anver, Majid Alam, Joerg Buddenkotte, Shahab Uddin, Martin Steinhoff
Published: 202610.1038/s41419-025-08389-z
Abstract
Cutaneous T-cell lymphoma (CTCL) is a progressive and heterogeneous malignancy characterized by deregulated metabolic reprogramming and cancer stemness, with limited therapeutic options. Therefore, elucidating the mechanisms driving metabolic reprogr…
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