Cell death & disease
ATGL suppresses ferroptosis in acute myeloid leukemia cells by modulating the CEBPα/SCD1 axis and induces gilteritinib resistance.
Shiyi Yuan, Ying Zhou, Wenrui Xiao, Ning Liu, Ping Zhang, Ying Zhang, Jianchuan Deng, Liang Fang, Xi Zhang, Shifeng Lou
Published: 202610.1038/s41419-025-08388-0
Abstract
Metabolic reprogramming disrupts energy homeostasis and promotes tumor cell proliferation. In the present study, high expression of adipose triglyceride lipase (ATGL) in patients with acute myeloid leukemia (AML) predicted a poor clinical prognosis.…
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