Cell death & diseaseRibosomal ProteinsHumansTOR Serine-Threonine KinasesProto-Oncogene Proteins c-aktSignal Transduction
RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells.
Xiaofei He, Daijiao Ye, Jiayao He, Gangfeng Ding, Zihan Lin, Yaqian Qin, Bin Zhou, Liuzhi Shi, Xuanyu Yu, Chen Meng, Min Li, Chongyun Xing, Shenmeng Gao
Published: 202510.1038/s41419-025-08379-1
Abstract
Ribosomal protein L5 (RPL5) is considered a haplo-insufficient tumor suppressor by upregulating p53 expression or promoting the inactivation of c-Myc in solid tumors upon tumor initiation. However, its detailed effect and mechanism in tumor maintenan…
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