Cell death & diseaseAnimalsDNA Polymerase gammaHumansSaccharomyces cerevisiaeDisease Models
Model organisms in POLG-related disorders: insights from yeast to multicellular systems.
Raquel Brañas Casas, Giovanni Risato, Alessandro Zuppardo, Carlo Viscomi, Francesco Argenton, Mara Doimo, Nicola Facchinello, Natascia Tiso
Published: 202510.1038/s41419-025-08366-6
Abstract
Mitochondrial genetic diseases are complex disorders that impair cellular energy production, leading to diverse clinical manifestations across multiple organ systems. These diseases arise from mutations in either mitochondrial DNA or nuclear DNA. Amo…
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