Cell death & diseaseAnimalsPyroptosisMicrogliaInterferon Type IMice
Unlocking microglia pyroptosis in a model of type I interferon-driven neuroinflammation: lessons from Rnaset2-/- mice.
Kristin Wendland, Milena Irsfeld, Kathrin Schreiber, Katharina Ternka, Christine Stadelmann, Stefan Nessler, Jutta Gärtner, Matthias Kettwig
Published: 202510.1038/s41419-025-08350-0
Abstract
RNaseT2-deficient cystic leukoencephalopathy (CLE) presents with severe psychomotor retardation, cystic brain lesions, white matter alterations, and cerebral atrophy. The Rnaset2-/- mouse mirrors key features of this disease and represents the first…
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