Cell death & diseaseAnimalsCarcinomaHepatocellularLiver NeoplasmsCell Proliferation
Targeting MED23 inhibits hepatocellular carcinoma development by suppressing compensatory proliferation and facilitating ROS-mediated cell death.
Xiaying Zhao, Zhichao Wang, Lihua Min, Dan Cao, Yajing Chu, Chonghui Li, Jiabin Cai, Gang Wang
Published: 202510.1038/s41419-025-08348-8
Abstract
Hepatocellular carcinoma (HCC) is frequently linked to compensatory proliferating hepatocytes in damaged livers, yet the underlying molecular mechanisms remain elusive. The Mediator complex precisely coordinates multiple transcription factors and cof…
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