Cell death & diseaseHumansNucleophosminSumoylationLung NeoplasmsNuclear Proteins
SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3's activity and promotes lung tumorigenesis.
Xiangyu Meng, Weize Wang, Namratha Sheshadri, Tianyu Zhang, Xinlu Han, Yifu Sun, Man Xiao, Yu Feng, Shan Gao, Jian Chen, Sisi Xie, Yongbo Wang, Yunlong Yang, Yanxiang Zhao, Yuxin Yin
Published: 202510.1038/s41419-025-08347-9
Abstract
SERPINB3 or SCCA1, a member of the serine proteinase inhibitor family, is frequently overexpressed in multiple malignancies, including lung adenocarcinoma (LUAD). However, its molecular mechanisms and endogenous substrates in lung cancer remain poorl…
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