Cell death & diseaseHumansFerroptosisUrinary Bladder NeoplasmsSmad3 ProteinCell Line
Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells.
Yulin Sun, Jianghui Wang, Da Gu, Huanmin Lou, Jinpeng Sun, Zilian Cui, Weiting Kang
Published: 202510.1038/s41419-025-08339-9
Abstract
The poor prognosis of bladder cancer (BCa) is primarily attributed to the acquisition of invasive and metastatic capabilities by tumor cells through epithelial-mesenchymal transition (EMT), yet the dynamic alterations in ferroptosis during EMT and th…
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