Cell death & diseaseHumansLiver NeoplasmsCarcinomaHepatocellularOxaliplatin
CUL4B promotes hepatocellular carcinoma progression and oxaliplatin resistance by facilitating FUS degradation.
Jun-Dong Wei, Kai Cheng, Xiaoyu Wu, Luyi Zhang, Qinle Wang, Yetian Liang, Ziqi Zhu, Weijia Meng, Wangyang Chen, Xingang Guan, Hui Yang, Lisha Zhou
Published: 202510.1038/s41419-025-08320-6
Abstract
Cullin4B (CUL4B), which functions as a scaffold protein within the CUL4B-RING ubiquitin ligase complex (CRL4B), is frequently overexpressed in various cancers and exhibits oncogenic characteristics. However, its specific role in hepatocellular carcin…
Preview only. Read the full abstract at the source