Cell death and differentiation
TUFT1 stabilizes TGF-β receptor II protein and facilitates activation of hepatic stellate cells into metastasis-promoting myofibroblasts.
Yue Li, Yu Shi, Yaxin Fu, Lianying Jiao, Hanqi Li, Lu Shao, Xuelian Xiao, Ningling Kang, Liankang Sun, Kangsheng Tu
Published: 202610.1038/s41418-026-01664-2
Abstract
Cancer-associated fibroblasts (CAFs) transdifferentiated from hepatic stellate cells (HSCs) are a critical determinant of liver metastasis of colorectal cancer (CRC). However, the mechanisms behind transforming growth factor β (TGF-β)-stimulated acti…
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