Cell death and differentiation
EGFR orchestrates neutrophil activation and NETosis via CEBPβ-dependent PGLYRP1 induction.
Xiaolei Liu, Yue Lu, Yuanbo Guo, Guorong Huang, Jiahui Li, Jingran Lin, Zhijie Li, Liangqing Zhang, Hanhui Zhong, Yiwen Zhang, Jing Tang
Published: 202610.1038/s41418-026-01660-6
Abstract
Excessive neutrophil activation and neutrophil extracellular trap (NET) release drive systemic inflammation and organ injury in sepsis, yet the upstream regulatory pathways remain incompletely defined. Here, we identify epidermal growth factor recept…
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