Cell death and differentiation
ERK/Smurf1 regulates non-canonical pyroptosis by prompting Caspase-11 ubiquitination.
Chenglong Zhu, Wangzheqi Zhang, Yan Liao, Ruoyu Jiang, Lindong Cheng, Yi Wang, Tian Zhou, Yijie Tao, Sheng Xu, Yizhi Yu, Zui Zou
Published: 202610.1038/s41418-025-01654-w
Abstract
Sepsis, a devastating microbe-induced inflammatory response, culminates in multi-organ dysfunction, with pyroptosis mediated by the non-canonical inflammasome being a pivotal factor. The mouse Caspase-11, central to this pathway, is directly activate…
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