Cell death and differentiation
Galectin-9 activates microglial asparagine endopeptidase and promotes α-synuclein pathology in Parkinson's disease.
Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Xu Xu, Yiming Li, Lina Pan, Lanxia Meng, Jing Xiong, Sheng Li, Zhentao Zhang
Published: 202510.1038/s41418-025-01640-2
Abstract
Parkinson's disease (PD) is characterized by the aggregation of misfolded α-synuclein (α-syn) and microglial activation. Galectin-9 (Gal-9) is an immunoregulatory mediator generated by microglia. Here, we found that α-syn fibrils are internalized by…
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