Cell death and differentiation
CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosome secretion via TRIM56-mediated ubiquitination and degradation of GCN2.
Jie Yang, Chenggong Liao, Xiaohua Liang, Yuan Ke, Ying Sun, Minmin Huang, Meirui Qian, Xu Yang, Hongyong Cui, Huijie Bian, Zhinan Chen, Lingmin Kong
Published: 202510.1038/s41418-025-01636-y
Abstract
Tumor-derived exosome secretion dynamically correlates with malignant progression, although the mechanisms by which tumor-associated antigens regulate exosome production remain unclear. Here, we found that the number of plasma exosomes increased sign…
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