Cell death and differentiation
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss.
Xianyu Piao, Ju Han Song, Jung-Woo Kim, Seung-Hee Kwon, Sin-Hye Oh, Sangita Sharma, Suk-Gyun Park, Zhao Wang, Zhiyu Fang, Je-Hwang Ryu, Nacksung Kim, Jeong-Tae Koh
Published: 202510.1038/s41418-025-01596-3
Abstract
Osteoclasts are essential for bone remodeling; however, their hyperactivity leads to pathological bone loss. While inflammasome-activated caspases are known to influence osteoclastogenesis, the role of caspase-11, beyond its conventional function in…
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