British journal of cancer
Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes.
Jiawen Yang, John M Ryniawec, Diogo de Oliveira Pessoa, Matthew R Coope, Daniel W Buster, Emily Loertscher, Mengdie Wang, Chen Chen, Anne E Cress, Megha Padi, Gregory C Rogers
Published: 202610.1038/s41416-025-03323-8
Abstract
BACKGROUND: Chromosomal instability (CIN) is a hallmark of prostate cancer that strongly correlates with metastatic burden and appears prominently in both primary cancer and metastatic disease. Low Gleason score primary prostate tumors display pervas…
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