British journal of cancer
Breast cancer incidence and subtype patterns among BRCA-mutated ovarian cancer patients: a systematic review and meta-analysis.
Pedro Henrique de Souza Wagner, Gustavo Tadeu Freitas Uchôa Matheus, Danilo Monteiro Ribeiro, Maria Cristina Figueroa Magalhães, Francisco Cezar Aquino de Moraes
Published: 202510.1038/s41416-025-03320-x
Abstract
BACKGROUND: BRCA1 and BRCA2 are tumor suppressor genes essential for DNA repair. Mutations in these genes significantly increase breast (BC) and ovarian cancer (OC) risk, with BRCA1-positive facing a 70% BC and 40% OC lifetime risk. While guidelines…
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