British journal of cancer
Lifetime risk of solid tumors and leukemia in Down Syndrome: a population-based Swedish matched cohort study.
Alexandra Wachtmeister, Benedicte Bang, Ida Nordgren, Anna Martling, Bertil Johansson, Yunxia Lu, Anna Skarin Nordenvall, Giorgio Tettamanti, Ann Nordgren
Published: 202510.1038/s41416-025-03318-5
Abstract
BACKGROUND: Individuals with Down syndrome have an elevated risk of childhood leukaemia and are suggested to have a reduced risk of solid tumours in adulthood. However, it remains unclear which cancer subtypes contribute to this pattern and the lifet…
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