British journal of cancer
Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C.
Kyah van Megesen, Arianna Stefan, Madelief Kieboom, Rebecca Amico, Anne M L Jansen, Inne Borel Rinkes, Onno Kranenburg
Published: 202610.1038/s41416-025-03310-z
Abstract
BACKGROUND: A minority of Colorectal Cancer (CRC) patients with peritoneal metastases is eligible for cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). However, recurrence rates are high (~80%). We tested whet…
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