British journal of cancer
Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features.
Ville K Äijälä, Jouni Härkönen, Päivi Sirniö, Tuomo Mantere, Hanna Elomaa, Onni Sirkiä, Akseli Kehusmaa, Henna Karjalainen, Meeri Kastinen, Vilja V Tapiainen, Maarit Ahtiainen, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen
Published: 202510.1038/s41416-025-03300-1
Abstract
BACKGROUND: Uroplakin-2 (UPK2) is a relatively specific marker for urothelial cancer, often used in the differential diagnosis of tumors of unknown origin. UPK2 expression has been observed in colorectal cancers (CRCs), prompting further investigatio…
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