Acta pharmacologica Sinica
A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting.
Wen-Bin Pei, Zi-Yu Lei, Fu-Quan Xie, Peng Chen, Yong-Cheng Su, Yu-Shan Qin, Jiang-Quan Li, Qian-Wen Shen, Miao-Miao Ma, Chun-Yi Gao, Jia-Chen Zhu, Ya-Jie Xu, Kai-Yue Zhang, Wen-Qing Zhang, Yan-Dong Zhang
Published: 202610.1038/s41401-025-01728-y
Abstract
Photodynamic therapy (PDT) boasts the advantages of high spatiotemporal selectivity and non-invasiveness, but its clinical application is still limited by the hypoxic tumor microenvironment and inherent drawbacks of traditional photosensitizers such…
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