Acta pharmacologica Sinica
Targeting intrinsic and CAF-mediated signaling by PI3Kα inhibitor CYH33 attenuated metastasis in lung squamous cell carcinoma.
Xiao-Yu Ma, Jie-Ting Deng, Zhe-Rui Cao, Lan Xu, Jian Ding, Ling-Hua Meng
Published: 202610.1038/s41401-025-01719-z
Abstract
Aberrant activation of PI3K signaling is frequently observed in lung squamous cell carcinoma (LUSC) and is strongly associated with metastasis in advanced-stage patients, but the therapeutic efficacy of PI3K inhibitors and underlying mechanisms in LU…
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