Acta pharmacologica Sinica
UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice.
Qi-Mei Wu, Jing Liu, Ying-Song Mu, Juan Li, Ying-Jie Tian, Zhi Wang, Miao Deng, Yang-Mei Qiu, Shu Zhou, Zi-Yang Zhang, Xin-Mei Xu, Liang Ma, Ping Fu, Xiao-Yong Yan, Zhou-Ke Tan
Published: 202610.1038/s41401-025-01715-3
Abstract
The pathogenesis of acute kidney injury (AKI) is closely related to the senescence of renal tubular epithelial cells (RTECs). The role of small ubiquitin-like modification (SUMOylation) in cellular stress and senescence has been gradually elucidated.…
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