Acta pharmacologica Sinica
LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation.
Fei-Fei Xu, Hui-Min Sun, Yuan Liu, Kai Ye, Zhi-Yu Liu, Xue-Li Fu, Zhi-Tu Zhu, Wei-Ying Zhang, Li-Hong Ye
Published: 202610.1038/s41401-025-01687-4
Abstract
In the etiology of cancer, p62 is a well-known autophagic receptor and signaling adapter. High p62 expression is known to accelerate hepatocellular carcinoma (HCC) growth by activating various downstream signaling pathways. In this study, we investig…
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