Acta pharmacologica Sinica
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice.
Min-Chun Jiang, Huan-Yu Ding, Chak Kwong Cheng, Dong-Qin Cai, Hai-Xia Guan, Jian Kuang, Ronald Ching Wan Ma, Yin Xia, Xiao-Qiang Yao, Li Wang, Yu Huang
Published: 202510.1038/s41401-025-01672-x
Abstract
Atherosclerosis preferentially develops at arterial bifurcations where the endothelial cells are constantly exposed to disturbed flow, and sustained oscillatory shear stress (OSS) triggers endothelial inflammation. The mechanosensitive transcriptiona…
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