Acta pharmacologica Sinica
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway.
Qing Wu, Qi Su, Man Zhu, Tian-Feng Yang, Wen-Juan Tang, Yu Hu, Jia-Yan Ren, Xiu-Hong Peng, Su-Yu Zhang, Yan-Min Zhang
Published: 202510.1038/s41401-025-01670-z
Abstract
Resistance of non-small cell lung cancer (NSCLC) to EGFR tyrosine kinase inhibitors (TKIs) limits the efficacy and leads to disease progression with mechanisms such as activation of autophagy in tumor cells, but the current therapeutic strategies are…
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