Acta pharmacologica Sinica
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease.
Dan-Dan Zhong, Cheng Hu, Lan-Lan Zhao, Yan Shen, Ru-Meng Zhang, Ying Liu, Bu-Hui Liu, Wen Su, Bao-Xue Yang, Hui Xiong, Dong Guo, Dong Sun, Ying-Ying Zou, Ying Sun
Published: 202510.1038/s41401-025-01664-x
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of multiple fluid-filled cysts in the kidneys, resulting in progressive decline and failure of renal function. Microsomal prostaglandin E synthase-2 (mPGES-2) is…
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