ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval.

As antipsychotic administration often persists for a lifetime, antipsychotic-induced cardiotoxicity (AIC) becomes a significant and potentially life-threatening side effect. Owing to the lack of an appropriate human cardiomyocyte experimental model,…

Preview only. Read the full abstract at the source