Pediatric research
Deleterious variants in LTBP4 are associated with severe pediatric sepsis.
Yidi Qin, Kate F Kernan, Yulong Bai, John R Shaffer, Zsolt Urban, Scott Canna, Murray M Pollack, Kathleen Meert, Christopher Newth, Tom Shanley, Rick E Harrison, Mark Hall, Joseph A Carcillo, Hyun-Jung Park
Published: 202510.1038/s41390-025-04420-3
Abstract
BACKGROUND: Sepsis is a leading global health burden in children, and its unavoidable heterogeneity has hindered providing therapies beyond antibiotics and supportive care. Recently, we identified four computable phenotypes showing distinct cytokine…
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