OncogeneHumansCisplatinTOR Serine-Threonine KinasesDrug ResistanceNeoplasm
An H4K12la/CEBPB-AKR1C2 signaling axis modulates the mTOR pathway to regulate cisplatin resistance in lung cancer.
Wenjing Wang, Qiang He, Tianfei Fan, Yang Xiong, Yimin Xiong, Qinhui Liu, Na Yang, Yining Xu, Yanping Li, Jinhan He
Published: 202610.1038/s41388-025-03669-6
Abstract
Histone lactylation, a recently discovered epigenetic modification, has been shown to play a critical role in regulating gene expression and cellular functions. However, its involvement in cisplatin (CDDP) resistance in non-small cell lung cancer (NS…
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