OncogeneFemaleOvarian NeoplasmsHumansAnimalsMice
Dual-target CAR-T therapy for ovarian cancer: synergistic targeting of MSLN and B7H3 enhances anti-tumor efficacy and overcomes antigen heterogeneity.
Feng Ji, Kai Yan, Bo Ding, Yuxin Zhu, Mengchen Rao, Kexing Gao, Hao Lin, Yiyang Shan, Sicong Liu, Zhongdang Xiao, Yang Shen
Published: 202610.1038/s41388-025-03663-y
Abstract
Ovarian cancer (OC) remains a lethal malignancy with limited treatment options owing to antigen heterogeneity and an immunosuppressive tumor microenvironment (TME). Here, we designed a unique chimeric Antigen Receptor T-Cell (CAR-T) construct (B4M3)…
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