OncogeneCellular SenescencePolycomb Repressive Complex 1PhosphorylationHumansProtein Kinase C
Phosphorylation of CBX8 by PKD1 suppresses PRC1 activity and promotes cell senescence.
Zhiqiang Fang, Doudou Liu, Yuanyuan Su, Fengxin Hao, Ruodong Qin, Guodong Li, Jun Chen
Published: 202610.1038/s41388-025-03657-w
Abstract
The Polycomb group (PcG) protein chromobox 8 (CBX8) is the subunit of Polycomb repressive complex 1 (PRC1) and recognizes the trimethylation of histone H3 on Lysine 27 (H3K27me3), and coordinates with PRC2 complex to function as an epigenetic gene si…
Preview only. Read the full abstract at the source