OncogeneHumansOxaliplatinDrug ResistanceNeoplasmRNA-Binding Proteins
RBM8A confers oxaliplatin resistance in gastric cancer by maintaining EGFR mRNA stability.
Yichun Ma, Ying Xiang, Mei Yang, Yanmei Zhu, Yani Pan, Nannan Zhang, Xueni Fu, Ping Jiang, Yinya Pan, Hai Wu, Qiong Yan, Wenjun Li, Hongji Tao, Shangtao Mao, Yufei Tao
Published: 202610.1038/s41388-025-03655-y
Abstract
RNA-binding proteins (RBPs) critically regulate post-transcriptional gene expression, yet their roles in chemotherapy resistance remain underexplored. Here, through a targeted siRNA screen of 40 RBM family members, we identified RNA-binding motif pro…
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