OncogeneHumansEndoplasmic Reticulum StressProtein Disulfide-IsomerasesNasopharyngeal CarcinomaAutophagy
circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation.
Pingjuan Xiang, Le Tang, Yi Zhang, Juana Jessica Mendoza, Qijia Yan, Lei Shi, Bo Xiang, Zhaoyang Zeng, Pan Chen, Dan Wang, Wei Xiong
Published: 202610.1038/s41388-025-03652-1
Abstract
Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck with a high prevalence in Southeast Asia. Although radiotherapy remains the primary treatment modality, resistance to radiation in a subset of patients with advanced-stage disea…
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