OncogeneHumansProtein Tyrosine PhosphataseNon-Receptor Type 6STAT6 Transcription FactorAnimals
DARPP-32 is a novel regulator of M2-macrophage polarization: Sustains STAT6 phosphorylation by directly binding and inhibiting tyrosine phosphatase SHP-1.
Sangita Chowdhury, Arppita Sethi, Swati Srivastava, Vishal Upadhyay, Shivkant Mishra, Agniv Shome, Anil Kumar Singh, Shyam Singh, Madan Lal Brahma Bhatt, Anand Mishra, Arun Kumar Trivedi
Published: 202510.1038/s41388-025-03610-x
Abstract
Identifying novel factors driving M2-macrophage polarization may help understand immune modulation in cancers. We identified DARPP-32, a protein phosphatase inhibitor, to be significantly upregulated in FBXW7 knock out THP-1 spontaneously polarized t…
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