OncogeneTemozolomideGlioblastomaHumansChemokine CCL2Cancer-Associated Fibroblasts
Cytokine CCL2 secreted by cancer-associated fibroblasts augments temozolomide resistance in glioblastoma through ERK1/2 signaling.
Mingrong Zuo, Shuxin Zhang, Siliang Chen, Yuze He, Junhong Li, Yufan Xiang, Yunbo Yuan, Tengfei Li, Wanchun Yang, Zhihao Wang, Wenhao Li, Ni Chen, Yuan Yang, Yunhui Zeng, Qing Mao
Published: 202510.1038/s41388-025-03601-y
Abstract
The intricate tumor microenvironment largely influences chemoresistance in glioblastoma. Cancer-associated fibroblasts (CAFs) that modulate tumor progression have recently been identified as non-tumor stromal cells within the glioblastoma microenviro…
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