OncogeneGlioblastomaTranscription FactorsAnimalsHumansMice
BRD4 inhibition sensitizes glioblastoma to radiotherapy by suppressing super-enhancer-driven COL1A1.
Xichen Fan, Yi Yang, Xuenan Li, Li Yu, Yafei Wang, Ziheng Wang, Shubao Wang, Weichen Duan, Jiajia Chen
Published: 202510.1038/s41388-025-03596-6
Abstract
Radiotherapy (RT) combined with chemotherapy is the standard treatment for newly diagnosed glioblastoma (GBM). However, the limited RT efficacy and RT-related cancer resistance have spurred interest in radiosensitizing strategies for GBM. We aimed to…
Preview only. Read the full abstract at the source