Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaV1.7 and NaV1.8 nociceptive sodium channels.
Yossef Maatuf, Ariel Iskimov, Alexander M Binshtok, Avi Priel
Published: 202610.1038/s41386-026-02355-9
Abstract
Δ⁹-Tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, is widely recognized for its central effects mediated by cannabinoid receptors. Here, we uncover a distinct peripheral mechanism by which THC inhibits the excitability of n…
Preview only. Read the full abstract at the source