Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Epigenetic treatment of synaptic and behavioral deficits in Dyrk1a-mutant mice.
Chih-Hung Lin, Mingjun Yu, Prachetas Jai Patel, Pei Li, Zhen Yan
Published: 202610.1038/s41386-026-02353-x
Abstract
Haploinsufficiency of Dyrk1a, which encodes the dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), has been causally linked to autism. Here we examined transcriptomic, electrophysiological and behavioral alterations in mice carry…
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