Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [18F]Flubatine PET images.
Nakul R Raval, Katina C Calakos, Ming-Qiang Zheng, Anita Huttner, Irina Esterlis, Henry Huang, Vince D Calhoun, Marina R Picciotto, Kelly P Cosgrove, Ansel T Hillmer
Published: 202610.1038/s41386-025-02311-z
Abstract
Tobacco smoking, a major cause of preventable mortality, upregulates β2 subunit-containing nicotinic acetylcholine receptors (β2*-nAChR) in most brain regions. Although the α4 subunit most frequently co-assembles with β2, other subunits likely assemb…
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