Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving.
Laura L Huerta Sanchez, Natasha M Siao, Sanil R Chaudhari, Julie E Barrios, Audrey Y Na, Mirette G Tadros, Megan L McConnell, Rachel M Kaplan, Caden R Lane, Hoa H T Doan, Ashley B Liger, Tessa C Chou, Serena Marcon, Fernando J Cano, Tod E Kippin
Published: 202610.1038/s41386-025-02310-0
Abstract
The incubation of craving is a term coined to characterize the behavioral phenomenon wherein cue-elicited craving strengthens over a period of abstinence. Incubated cocaine-craving is mediated, at least in part, by increased glutamate release within…
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