Molecular psychiatry
In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer's disease continuum.
Douglas Teixeira Leffa, Guilherme Povala, Pamela C L Ferreira, João Pedro Ferrari-Souza, Guilherme Bauer-Negrini, Matheus Scarpatto Rodrigues, Livia Amaral, Firoza Z Lussier, Marina Scop Medeiros, Carolina Soares, Cristiano Schaffer Aguzzoli, Arthur C Macedo, Joseph Therriault, Pedro Rosa-Neto, Dana L Tudorascu
Published: 202510.1038/s41380-025-03400-7
Abstract
Intracellular alpha-synuclein aggregates, known as Lewy bodies (LB), are commonly observed in Alzheimer's disease (AD) dementia. Post-mortem studies have shown a higher frequency of neuropsychiatric symptoms among individuals with AD and LB co-pathol…
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