Molecular psychiatry
MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis.
Laura M Best, Jennifer Truong, Tina McCluskey, Jeffrey H Meyer, Pablo Rusjan, Shahtaj S Dheda, Jerlene Pandian, Vitor S Tardelli, Dafna Sara Rubin-Kahana, Shawn G Rhind, Bernard Le Foll, Jerry Warsh, Stephen J Kish, Isabelle Boileau
Published: 202510.1038/s41380-025-03355-9
Abstract
Chronic alcohol exposure may trigger astrogliosis-a process involving hypertrophy and upregulation of astrocyte-specific markers following neuronal stress or injury-as suggested by trends in preclinical studies. However, in vivo evidence of astroglio…
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