Molecular psychiatry
The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty.
Gerardo Leana-Sandoval, Alexis Madrid, Ananth V Kolli, Carlene A Chinn, Matthew A Sandoval, Iris Lo, Vanessa Alizo Vera, Jeffrey Simms, Marcelo A Wood, Javier Díaz-Alonso
Published: 202510.1038/s41380-025-03328-y
Abstract
The GluA1 subunit, encoded by the putative schizophrenia-associated gene GRIA1, is required for activity-regulated AMPA receptor (AMPAR) trafficking, and plays a key role in cognitive and affective function. The cytoplasmic, carboxy-terminal domain (…
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