Molecular psychiatryAnimalsOligodendrogliaLiver X ReceptorsCell SurvivalMice
Role of LXRβ in oligodendrocytes in neuronal survival.
Xiaoyu Song, Wanfu Wu, Mukesh Varshney, Andrew Roman, Jan-Åke Gustafsson, Margaret Warner
Published: 202610.1038/s41380-025-03278-5
Abstract
We have reported that mice in which the liver X receptor β (LXRβ) gene is inactivated lose dopaminergic neurons in the substantia nigra and motor neurons in the ventral horn of the spinal cord. These mice develop progressive hind limb paralysis start…
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