Near infrared light controlled gene editing.

A novel NIR light-activated CRISPR-dCas9/Cas9 system achieves precise and rapid gene regulation in living organism using a chemically cleavable rapamycin dimer. Unlike previous light-driven systems, this approach offers deeper tissue penetration, low toxicity, fast response, and minimal background activity. This platform opens new directions for highly efficient, targeted, noninvasive, and spatially confined gene editing for a great number of preclinical and clinically translatable applications.