Leukemia
Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia.
Fanny Gonzales, Constanze Schneider, Gabriela Alexe, Shan Lin, Delan Khalid, Montserrat Alvarez, Allen Basanthakumar, Jana M Ellegast, Lucy Merickel, Silvi Salhotra, Audrey Taillon, Mariateresa Giaimo, Mark Wunderlich, Marc Ansari, Jennifer A Perry
Published: 202610.1038/s41375-025-02845-7
Abstract
CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia (AML) remains one of the worst prognostic AML subgroups. To uncover innovative targeted therapy approaches in this disease subtype we performed genome-scale CRISPR-Cas9 screening that highlight…
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