Leukemia
The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.
Jonas Fullin, Ebru Topçu, Karolina A Zielińska, Roman R Schimmer, Nancy Klemm, Christian Koch, Francisco Caiado, Melissa Lock, Cyril Doerdelmann, Marco M Bühler, Joelle Tchinda, Kari J Kurppa, Lubor Borsig, Philip H Jones, Massimo Lopes
Published: 202510.1038/s41375-025-02839-5
Abstract
Therapy-related acute myeloid leukemia and myelodysplastic neoplasms (t-AML/MDS) are devastating complications of chemo- or radiation therapy in patients treated for an unrelated primary malignancy. Cancer patients with TP53-mutant hematopoietic stem…
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