LeukemiaHumansMultiple MyelomaGenetic Predisposition to DiseaseExome SequencingMale
Putative multiple myeloma susceptibility genes identified by exome sequencing of 347 familial and early-onset cases.
Maroulio Pertesi, Delphine Demangel, Abhishek Niroula, Emeline Perrial, Maria Laura Mahecha Escobar, Maxime Vallée, Christine Liacos, Mehmet K Samur, Adam S Sperling, Nikhil C Munshi, Efstathios Kastritis, Meletios A Dimopoulos, James D McKay, Ulf-Henrik Mellqvist, Markus Hansson
Published: 202610.1038/s41375-025-02802-4
Abstract
Multiple myeloma (MM) is the second most common blood malignancy, with several lines of evidence supporting an inherited genetic component. Here, we sequenced 177 affected individuals from 128 families, and 170 early-onset MM cases diagnosed before 5…
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