Journal of perinatology : official journal of the California Perinatal Association
Oral doxapram for apnea of prematurity: A randomized dosage trial.
Jane M Canning, Jacqueline A Hannam, Julena Ardern, Lisa C Mravicich, Michael P Meyer, Trusha J Purohit, Naibo Yin, Sara M Hanning, Christopher J D McKinlay
Published: 202510.1038/s41372-025-02463-2
Abstract
OBJECTIVE: To determine the feasibility of oral doxapram dosing in very preterm infants. STUDY DESIGN: Phase-two, open-label randomized trial (ACTRN12621001163897) of two oral doxapram regimens for ≥5 days: higher-dose 48 mg/kg, then 24 mg/kg/6 h vs.…
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